Buy Skin Care Online

Isotretinoin — The Medicine Dermatologists Recommend for Severe Acne

If you've been through antibiotics, topical retinoids, and hormonal treatments without lasting improvement, isotretinoin is often the next step — and for most patients, it works when nothing else has.

Isotretinoin reduces sebum production by up to 80%, normalises the skin cells lining hair follicles, and has direct anti-inflammatory effects. Most patients see significant improvement within 2–3 months and lasting remission after a full course — even after stopping the medicine.

Which Isotretinoin Brand Is Best?

All isotretinoin brands at MEDIONIX PHARMA contain the same active molecule at the same dose. The choice between them comes down to your dose requirements, your budget, and what your dermatologist recommends.

What Dose of Isotretinoin Do You Need?

Dosing is based on your body weight. Your dermatologist calculates a daily dose and a total cumulative dose target for the course — typically 120–150mg per kilogram of body weight. The course usually lasts 4–6 months.

• Low-dose protocols (0.25–0.4mg/kg/day) are gentler and used over longer periods — Acutret 5mg and Tretiva 5mg/10mg are ideal for this
• Standard dose (0.5–1mg/kg/day) — Isotroin 20mg or Tretiva 20mg for most adults
• High dose (1mg/kg/day) — Tretiva 30mg or 40mg for severe nodular or cystic acne in heavier patients
• Women of childbearing age must use two forms of contraception — isotretinoin causes severe birth defects
• Blood tests (liver, lipids) are required during treatment

Botox and Botulax — Not Just for Wrinkles

Botulinum Toxin Type A temporarily relaxes muscles by blocking nerve signals. In aesthetic medicine, this reduces dynamic wrinkles — the lines that form when you frown, squint, or smile. But Botox has many medical applications too.

• Aesthetic: forehead lines, frown lines (glabellar), crow's feet, lip lines, masseter reduction (jawline slimming)
• Medical: hyperhidrosis (excessive sweating), chronic migraine, blepharospasm, cervical dystonia, overactive bladder
• Allergan Botox: the original and most studied BTX-A product worldwide
• Botulax (Hugel, South Korea): a premium BTX-A biosimilar, used widely in aesthetic clinics and considered equivalent in potency
• Available in 50, 100, and 200 unit vials — supplied to registered medical and aesthetic practitioners

Tretinoin Cream and Pigmentation Treatments

Tretiheal Cream is available in three concentrations: 0.025% (gentle, for beginners and sensitive skin), 0.05% (standard for acne and early photoageing), and 0.1% in 20g (maximum strength for established photoageing, deep pigmentation, and treatment-resistant acne).

Tretinoin increases the rate at which skin cells turn over, unclogs pores, reduces blackheads, and stimulates collagen production over time. It takes 8–12 weeks to see significant results, and SPF50 sunscreen during the day is essential.

For hyperpigmentation and melasma, Melacare Cream and Melamet Cream 15g combine three active ingredients — hydroquinone (melanin inhibitor), tretinoin (cell turnover), and a low-potency corticosteroid (anti-inflammation). This triple combination is the most effective topical treatment available for melasma.