O-Stat 120mg Capsule — Orlistat 120mg view 1
    O-Stat 120mg Capsule — Orlistat 120mg view 2
    O-Stat 120mg Capsule — Orlistat 120mg view 3

    O-Stat 120mg Capsule

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    🩺Medically reviewed by Dr. Priya Sharma, PharmD, BCCP · Last reviewed: June 2025
    Generic:OrlistatFormat:Strip of 10 CapsulesStrength:120mgManufacturer:Sun Pharmaceutical IndustriesCategory:Weight Loss MedicinesAvailability:In Stock

    O-Stat 120mg Capsule

    contains Orlistat 120mg, the prescription-strength dose of this gastrointestinal lipase inhibitor. Taken three times daily with fat-containing meals, this dose blocks approximately 30% of dietary fat absorption, delivering greater caloric deficit and more significant weight loss than the 60mg dose. It is prescribed alongside a calorie-reduced, lower-fat diet as part of a comprehensive obesity management programme.

    Benefits:

    - Prescription-strength orlistat blocking ~30% of dietary fat absorption

    - Greater average weight loss than the 60mg dose in clinical trials

    - Reduces cardiovascular risk factors including blood pressure and LDL cholesterol

    - Improves blood glucose control in overweight patients with type 2 diabetes

    - Well-studied safety profile with over two decades of clinical use

    How It Works:

    At 120mg, orlistat provides more complete inhibition of gastric and pancreatic lipases compared to the 60mg dose. By preventing a larger fraction of dietary triglyceride hydrolysis, a greater quantity of fat is excreted unabsorbed in faeces. This results in a more substantial daily caloric deficit, accelerating weight loss when combined with dietary energy restriction. The mechanism is entirely local (gastrointestinal) with negligible systemic absorption, making it safe for long-term use.

    Dosage and Administration:

    Take one 120mg capsule three times daily with each main meal containing fat — either during the meal or within 1 hour after eating. If a meal is missed or contains no fat, the corresponding capsule may be omitted. The maximum approved dose is 120mg three times daily (360mg/day).

    Side Effects:

    Similar to 60mg but more pronounced if dietary fat intake is not reduced: oily stools, fatty or oily discharge, faecal urgency, increased defecation frequency, oily spotting, flatulence with oil, faecal incontinence. Uncommonly: soft stools, abdominal cramps. Rare: severe hepatic injury (monitor liver function if symptoms develop).

    Precautions:

    A daily fat-soluble multivitamin (A, D, E, K) should be taken at bedtime or 2 hours before or after orlistat. Contraindicated in chronic malabsorption syndrome, cholestasis, or orlistat hypersensitivity. Monitor warfarin anticoagulation as orlistat may alter vitamin K absorption. Monitor thyroid function if taking levothyroxine concurrently.

    O-stat Dosage Comparison Guide

    StrengthBest ForOnsetDurationLink
    60mgLower strength option30–60 minPer mealView →
    120mgMaximum strength variant30–60 minPer mealCurrent

    * Always consult your doctor before changing your dosage. This information is for educational reference only.

    Frequently Asked Questions

    Q1: What is O-Stat 120mg used for?

    O-Stat 120mg contains prescription-strength orlistat for weight management in obese adults (BMI ≥30) or overweight adults (BMI ≥28) with associated risk factors such as hypertension, diabetes, or hyperlipidaemia, used alongside a calorie-controlled diet.

    Q2: How much more effective is 120mg compared to 60mg?

    Orlistat 120mg blocks approximately 30% of dietary fat versus 25% for 60mg. In clinical trials, the 120mg dose produced modestly greater weight loss — an average of 4–7 kg more than placebo versus 3–5 kg more for 60mg, over 6 months with dietary changes.

    Q3: Do I need a prescription for O-Stat 120mg?

    Orlistat 120mg is a prescription-only medicine in most markets. Consult a licensed healthcare provider who will assess your BMI, medical history, and current medications before prescribing.

    Q4: How do I reduce oily stools on O-Stat 120mg?

    The best strategy is to limit fat intake to no more than 30% of total calories per meal (approximately 15–20g fat per meal). Distributing fat intake evenly across three meals also helps. Keeping a food diary can help you manage fat intake.

    Q5: Can I take O-Stat 120mg if I'm on blood thinners?

    Use with caution. Orlistat may reduce vitamin K absorption, potentially increasing the anticoagulant effect of warfarin or acenocoumarol. Your INR should be monitored closely when starting or stopping orlistat, and warfarin doses may need adjustment.

    Q6: Is O-Stat 120mg safe for elderly patients?

    No specific dose adjustment is required for elderly patients. However, elderly individuals with pre-existing GI conditions or those on multiple medications (particularly fat-soluble vitamins or levothyroxine) should use orlistat with greater caution and medical supervision.

    Q7: Can I take O-Stat 120mg during Ramadan fasting?

    Orlistat is taken with fat-containing meals. During periods of fasting, there may be no appropriate meal to take the capsule with. Discuss with your prescriber how to manage orlistat dosing during prolonged fasting periods.

    Q8: Does O-Stat 120mg affect cholesterol?

    Yes. By blocking dietary fat absorption, orlistat reduces the absorption of cholesterol from food, leading to modest reductions in total LDL cholesterol in many patients — an additional cardiovascular benefit beyond weight loss alone.

    Q9: Can orlistat 120mg be used indefinitely?

    Orlistat has been studied for up to 4 years of continuous use with a demonstrated safety profile. Long-term use may be appropriate in patients who benefit from sustained treatment, under periodic medical review to reassess benefits and nutritional status.

    Q10: What should I do if I accidentally take too many capsules?

    If you take more than the prescribed three capsules per day, you may experience intensified GI side effects. Contact your prescriber or a pharmacist. There is no specific antidote; supportive management of GI symptoms is recommended.

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    Disclaimer

    The information provided on Medionix Pharma is intended for general informational purposes only. It should not be considered as medical advice, diagnosis, or treatment. Always consult a qualified healthcare professional before using any medication or starting any treatment.

    Medionix Pharma does not encourage self-medication. Customers are responsible for ensuring that purchases comply with local laws and prescription requirements in their country. If you have any questions or concerns regarding the content on our website, please contact us at sales@medionixpharma.com.

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