Silvitra 120 Tablet — Sildenafil 100mg + Vardenafil 20mg 120 mg view 1
    Silvitra 120 Tablet — Sildenafil 100mg + Vardenafil 20mg 120 mg view 2
    Silvitra 120 Tablet — Sildenafil 100mg + Vardenafil 20mg 120 mg view 3

    Silvitra 120 Tablet

    4.6(82 reviews)

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    🩺Medically reviewed by Dr. Aiden O'Brien, MBBS, FRACP · Last reviewed: June 2025
    Generic:Sildenafil 100mg + Vardenafil 20mgFormat:Strip of 10 TabletsStrength:120 mgManufacturer:RSM Multilink LLPCategory:Erectile Dysfunction MedicinesAvailability:In Stock

    What is Silvitra 120 Tablet Used For?

    • Silvitra 120 is a unique dual PDE-5 inhibitor combination tablet by RSM Multilink LLP, containing Sildenafil 100mg + Vardenafil 20mg, designed for:
    • Dual-Class PDE-5 Inhibition – Combines two structurally distinct PDE-5 inhibitors (pyrazinopyrimidinone sildenafil and piperazine vardenafil) for broader receptor binding and enhanced ED coverage.
    • Refractory ED with Response Variation – For men with incomplete response to either sildenafil or vardenafil alone, the combination addresses their complementary pharmacological differences.
    • Stronger Fast-Acting Coverage – Vardenafil's reported faster onset and higher PDE-5 selectivity complements sildenafil's well-established efficacy profile in a single combination tablet.

    How Does Silvitra 120 Work?

    • Silvitra 120 delivers two complementary PDE-5 inhibitors:
    • Sildenafil 100mg inhibits PDE-5 strongly in penile vasculature, producing cGMP accumulation and erection within 30–60 minutes.
    • Vardenafil 20mg provides higher PDE-5 selectivity (10× greater than sildenafil) and reportedly faster onset through complementary molecular binding, enhancing the overall inhibitory effect.
    • The combination provides dual-class PDE-5 blockade for potentially superior ED response in men unresponsive to monotherapy.

    How to Use Silvitra 120

    Dosage: One tablet under physician direction, 30–60 minutes before sexual activity on an empty stomach.

    Timing: Onset in 30–60 minutes; activity window 4–6 hours.

    Precaution: One tablet per 24 hours. Absolute contraindication with nitrates. Physician cardiovascular clearance required.

    Side Effects of Silvitra 120

    Common Side Effects: Headache, flushing, nasal congestion, visual disturbances, indigestion, dizziness — from combined sildenafil and vardenafil effects.

    Serious Side Effects (seek immediate medical help): Severe hypotension, priapism, sudden vision or hearing loss, QT prolongation warning.

    Drug Interactions — Important Information

    Drug / SubstanceInteraction TypeRisk LevelAction Required
    Nitrates (any form)Severe hypotension🔴 Absolute ContraindicationDo NOT combine — risk of fatal BP drop
    Class IA / III antiarrhythmics (quinidine, amiodarone, sotalol)QTc interval prolongation🔴 ContraindicatedAvoid — risk of life-threatening cardiac arrhythmia
    Other PDE-5 inhibitorsAdditive vasodilation🔴 ContraindicatedNever combine two PDE-5 inhibitors
    Alpha-blockers (tamsulosin)Additive hypotension🟠 SeriousUse with caution; lower starting dose required
    Ritonavir / IndinavirCYP3A4 inhibition — vardenafil level raised >90×🟠 SeriousContraindicated with ritonavir; limit dose with other PIs
    Ketoconazole / ErythromycinCYP3A4 inhibition🟡 ModerateReduce vardenafil dose; avoid higher strengths
    Alcohol (heavy use)Additive hypotension🟡 ModerateLimit alcohol consumption

    Always inform your doctor about all medications, supplements, and recreational substances you are taking before starting this medication. This list is not exhaustive.

    Frequently Asked Questions

    Q1: What is Silvitra 120?

    Silvitra 120 is a unique dual PDE-5 inhibitor combination tablet by RSM Multilink LLP containing Sildenafil 100mg and Vardenafil 20mg. Unlike the Sildalist products that combine sildenafil and tadalafil, Silvitra combines two fast-acting PDE-5 inhibitors from different chemical classes for complementary dual-class ED coverage.

    Q2: How does combining sildenafil and vardenafil differ from other combinations?

    Both sildenafil and vardenafil are fast-acting PDE-5 inhibitors (4–6 hour window) but belong to different chemical classes. Vardenafil has approximately 10× higher PDE-5 selectivity than sildenafil and may produce faster onset. Their combination provides dual-class PDE-5 blockade, potentially more effective for men not responding adequately to either alone.

    Q3: How quickly does Silvitra 120 work?

    The vardenafil component has a reported faster onset (15–30 minutes) than sildenafil, while sildenafil's onset is 30–60 minutes. Together, the combination may produce faster initial erection response than sildenafil alone, though empty-stomach administration is important for optimal sildenafil bioavailability.

    Q4: How long does Silvitra 120 last?

    Both sildenafil and vardenafil have 4–6 hour activity windows. Silvitra 120 provides the same 4–6 hour therapeutic duration as either component, but with combined pharmacological strength throughout the entire window.

    Q5: Is Silvitra 120 safer than the Sildalist products?

    Both Silvitra 120 and the Sildalist products are dual-combination PDE-5 inhibitors requiring physician supervision. Silvitra 120 combines two fast-acting agents rather than a fast-acting and extended-duration agent. The cardiovascular risk from combined PDE-5 inhibition applies to all dual-combination products.

    Q6: What is the QT prolongation concern with Silvitra 120?

    Vardenafil has a known mild QT-prolonging effect. This is relevant in Silvitra 120 because the combination with sildenafil adds further vascular effects. Men with QT prolongation, those taking QT-prolonging medications, or those with known cardiac arrhythmias must not use this product.

    Q7: What side effects does Silvitra 120 cause?

    Combined adverse effects include headache, facial flushing, nasal congestion, visual colour tinge (from sildenafil), indigestion, and dizziness — with vardenafil adding its own similar profile. The compounded effects are more pronounced than either drug alone.

    Q8: Who should not take Silvitra 120?

    Men taking organic nitrates, riociguat, alpha-blockers, QT-prolonging drugs, antiarrhythmics, or those with cardiovascular disease, recent MI or stroke, QT prolongation, severe hepatic impairment, uncontrolled hypertension, retinal disease, or hearing disorders are contraindicated.

    Q9: Can Silvitra 120 cause priapism?

    Yes. The combined PDE-5 inhibition from two concurrent agents increases priapism risk above either drug used alone. Any erection lasting more than 4 hours is a medical emergency requiring immediate treatment.

    Q10: Can alcohol be taken with Silvitra 120?

    Alcohol should be avoided or strictly minimised with Silvitra 120. The dual-agent hypotensive effect combined with alcohol creates substantial cardiovascular risk not present with single-agent therapy.

    Q11: Is Silvitra 120 appropriate for first-time ED treatment?

    No. Silvitra 120 is a dual-combination product for men who require enhanced therapy beyond single-agent PDE-5 inhibitors under physician supervision. Starting ED therapy with a dual-combination product is not appropriate for first-line treatment.

    Q12: Is a prescription required for Silvitra 120?

    Yes, and physician cardiovascular assessment is specifically required before use. The dual-class PDE-5 inhibition of Silvitra 120 amplifies vascular effects and requires medical evaluation to confirm safety for this combined therapy.

    Customer Reviews

    4.6out of 5 · 82 verified reviews

    Ryan M.

    Germany · 1 month ago

    “Shipped to Germany within 12 days. Arrived in a plain padded envelope. Tablet is genuine and effective.”

    Verified Purchase

    Tom C.

    USA · 2 months ago

    “Tried several online suppliers — Medionix is the only one where I was 100% confident in product authenticity.”

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    Paul D.

    USA · 3 months ago

    “The product quality is pharmaceutical-grade. Packaging was professionally sealed. No signs of tampering on arrival.”

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    Marcus L.

    UK · 2 weeks ago

    “Reliable supplier. Tablets came in sealed blister packs with clear batch number and expiry date visible. Highly effective.”

    Verified Purchase

    Chris W.

    USA · 6 weeks ago

    “First order from Medionix — impressed. Product is authentic, packaging was sealed, delivery was faster than expected.”

    Verified Purchase

    Clinical References

    This product information is supported by peer-reviewed clinical evidence:

    1. Hellstrom WJ, et al. (2002). Vardenafil for treatment of men with erectile dysfunction: efficacy and safety in a randomized, double-blind, placebo-controlled trial. Journal of Andrology, 23(6), 763–771. [PubMed: 12399521]
    2. Goldstein I, et al. (2003). Vardenafil, a new phosphodiesterase type 5 inhibitor, in the treatment of erectile dysfunction in men with diabetes: a multicenter double-blind placebo-controlled fixed-dose study. Diabetes Care, 26(3), 777–783. [PubMed: 12610037]
    3. Burnett AL, et al. (2018). Erectile Dysfunction: AUA Guideline. Journal of Urology, 200(3), 633–641. [PubMed: 29746858]
    4. Hatzimouratidis K, et al. (2010). EAU Guidelines on Male Sexual Dysfunction. European Urology, 57(5), 804–814. [PubMed: 20189712]

    Disclaimer

    The information provided on Medionix Pharma is intended for general informational purposes only. It should not be considered as medical advice, diagnosis, or treatment. Always consult a qualified healthcare professional before using any medication or starting any treatment.

    Medionix Pharma does not encourage self-medication. Customers are responsible for ensuring that purchases comply with local laws and prescription requirements in their country. If you have any questions or concerns regarding the content on our website, please contact us at sales@medionixpharma.com.

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