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Prolomet XL 100 Mg Tablet
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What is Prolomet XL 100mg Used For?
- Hypertension — higher dose for patients requiring stronger beta-blockade.
- Chronic stable angina — significant reduction in chest pain at this dose.
- Chronic heart failure (HF-rEF) — 100mg is an advanced target dose after gradual titration.
- Post-MI cardiac protection and heart rate control in atrial fibrillation.
How Does Prolomet XL 100mg Work?
- Metoprolol Succinate is a cardioselective beta-1 adrenergic receptor blocker.
- Reduces heart rate, myocardial contractility, and blood pressure by blocking beta-1 receptors in the heart.
- Extended-release (XL) formulation delivers Metoprolol gradually over 24 hours for stable, consistent drug levels.
- Cardioselectivity minimises effects on beta-2 receptors in the lungs compared to non-selective beta-blockers.
How to Use Prolomet XL 100mg
Dosage: 100mg once daily; only prescribed after successful titration from lower doses (12.5mg → 25mg → 50mg).
Timing: Take in the morning at the same time each day; may be taken with or without food.
Precaution: Swallow whole — do not crush, chew, or break. Do NOT stop abruptly — taper over 2+ weeks.
Side Effects of Prolomet XL 100mg
Common Side Effects: Bradycardia, fatigue, cold extremities, dizziness, depression, sleep disturbances.
Serious Side Effects (seek medical help): Severe bradycardia, complete heart block, worsening heart failure, severe bronchospasm.
Benefits
- Higher dose for robust beta-blockade in hypertension, angina, and heart failure.
- Sun Pharma-manufactured product with consistent bioavailability standards.
- Extended-release formulation for once-daily dosing with smooth 24-hour coverage.
- Proven cardiovascular mortality reduction in heart failure (MERIT-HF trial).
- Can be combined with Amlodipine or ARBs for additional blood pressure control.
Warnings and Precautions
- Do NOT stop abruptly — sudden discontinuation may precipitate rebound angina, MI, or severe hypertension. Taper gradually over 2+ weeks.
- Contraindicated in severe bradycardia, AV block (>1st degree), cardiogenic shock, and decompensated heart failure.
- Cardioselectivity is less pronounced at 100mg — use with extra caution in asthma or COPD.
- Masks tachycardia as a warning sign of hypoglycaemia — extra care in insulin-dependent diabetic patients.
- Monitor resting heart rate; consult your doctor if consistently below 55 bpm.
Drug Interactions
- Calcium channel blockers (verapamil, diltiazem): serious bradycardia and AV block risk — avoid combination.
- Digoxin: additive AV conduction slowing — monitor heart rate and digoxin levels.
- Insulin and antidiabetics: Metoprolol masks hypoglycaemia tachycardia — monitor blood glucose.
- Antiarrhythmics (amiodarone, flecainide): increased risk of conduction abnormalities.
Storage Information
- Store below 25°C, protect from moisture and heat.
- Keep in original packaging and out of reach of children.
- Other Metoprolol XL brands available at Medionix Pharma include Gudpres XL, Metocard XL, Metzok, Seloken XL, and Starpress XL — all containing Metoprolol Succinate extended-release.
Frequently Asked Questions
Q1: What is Prolomet XL 100mg used for?
Prolomet XL 100mg is a higher dose for patients requiring stronger beta-blockade for hypertension, chronic stable angina, chronic heart failure (HF-rEF), post-MI cardiac protection, and heart rate control in atrial fibrillation.
Q2: Why is 100mg only reached by titration?
Beta-blockers must be increased gradually to allow haemodynamic adaptation. Starting at 100mg without prior dose escalation can cause severe bradycardia, hypotension, or worsening heart failure.
Q3: How does Metoprolol Succinate 100mg work?
Metoprolol blocks beta-1 adrenergic receptors in the heart, reducing heart rate, myocardial contractility, and blood pressure. The extended-release formulation maintains stable drug levels for 24-hour coverage.
Q4: Can I crush or break Prolomet XL 100mg tablets?
No. Prolomet XL is an extended-release tablet. Crushing or breaking destroys the controlled-release mechanism. Swallow the tablet whole with water.
Q5: Can I stop Prolomet XL 100mg suddenly?
Absolutely not. Abrupt withdrawal at 100mg can cause severe rebound angina, myocardial infarction, or dangerous hypertension. Taper very gradually over 2 to 4 weeks under close medical supervision.
Q6: What are the common side effects at 100mg?
At 100mg, bradycardia, fatigue, cold extremities, dizziness, depression, and sleep disturbances are more likely than at lower doses. Report a resting heart rate below 55 bpm to your doctor.
Q7: Is Prolomet XL 100mg safe for patients with asthma or COPD?
Extra caution is needed at this dose. Cardioselectivity is less pronounced at higher doses, increasing the risk of bronchospasm. Discuss the benefit-risk balance carefully with your doctor.
Q8: Does Prolomet XL 100mg mask hypoglycaemia?
Yes. Metoprolol masks the rapid heartbeat that signals low blood sugar in insulin-dependent diabetics. Sweating is still present as a warning sign. Frequent blood glucose monitoring is essential.
Q9: What medicines should I avoid with Prolomet XL 100mg?
Avoid verapamil and diltiazem (serious bradycardia and heart block risk). Digoxin combined with Metoprolol further slows conduction. Inform your doctor of all medicines including antiarrhythmics.
Q10: What should I monitor on Prolomet XL 100mg?
Monitor resting heart rate regularly. If below 55 bpm consistently, contact your doctor immediately. Watch for worsening heart failure symptoms: breathlessness, sudden weight gain, or swelling.
Q11: Can Prolomet XL 100mg be combined with other medicines?
Yes. It is frequently combined with amlodipine, ARBs, or ACE inhibitors. Do not combine with verapamil or diltiazem without specific medical guidance.
Q12: How should I store Prolomet XL 100mg?
Store below 25°C in a cool, dry place protected from moisture and heat. Keep in original packaging and out of reach of children.
Customer Reviews
Priya Sharma
India · 1 month ago
“Prompt response from the team and smooth ordering process. Medicine arrived in original sealed packaging as expected.”
FirstCare Clinic
Canada · 3 months ago
“Good value for bulk procurement orders. Communication was clear and the shipment arrived within the estimated timeframe.”
Dr. Maria Santos
Australia · 3 weeks ago
“Good quality product. Shipping was fast and handled with care. Would recommend for professional hospital procurement.”
Michael K.
USA · 2 months ago
“Fast international shipping and professional packaging. Product was exactly as described. Highly recommend this supplier.”
Dr. James Wilson
USA · 1 week ago
“Excellent product quality. Arrived well-packaged with proper cold chain maintained throughout transit. Will order again.”
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Disclaimer
The information provided on Medionix Pharma is intended for general informational purposes only. It should not be considered as medical advice, diagnosis, or treatment. Always consult a qualified healthcare professional before using any medication or starting any treatment.
Medionix Pharma does not encourage self-medication. Customers are responsible for ensuring that purchases comply with local laws and prescription requirements in their country. If you have any questions or concerns regarding the content on our website, please contact us at sales@medionixpharma.com.