Nervigesic 150 Capsule

Q1: What is Nervigesic 150 (Pregabalin 150mg) used for?

Nervigesic 150 is used to treat neuropathic pain including diabetic peripheral neuropathy (burning, tingling pain in the feet and legs from diabetes) and post-herpetic neuralgia (lingering nerve pain after shingles). It is also used as an add-on treatment for partial seizures in epilepsy, for fibromyalgia, and for generalised anxiety disorder (GAD).

Q2: How does Pregabalin reduce nerve pain?

Pregabalin binds to the alpha-2-delta subunit of voltage-gated calcium channels on overactive pain-transmitting nerves. This reduces calcium influx into the nerve ending, decreasing the release of excitatory neurotransmitters (glutamate, substance P, norepinephrine) that amplify pain signals. The result is a 'quietening' of hyperactive pain pathways characteristic of neuropathic conditions.

Q3: How long does it take for Nervigesic 150 to work?

For neuropathic pain and fibromyalgia, noticeable pain reduction usually begins within 1–2 weeks of reaching the effective dose, with maximum benefit at 4 weeks. For generalised anxiety disorder, many patients notice reduced anxiety within the first week — faster than most antidepressants used for anxiety. For epilepsy, antiseizure effect integrates into the overall treatment plan over time.

Q4: What is the difference between Nervigesic 150mg and Nervigesic 300mg?

Both contain Pregabalin and work identically. Nervigesic 150mg (150mg per capsule, taken twice daily = 300mg/day) is the standard starting effective dose for neuropathic pain and fibromyalgia. Nervigesic 300mg (300mg per capsule, typically taken twice daily = 600mg/day) is for patients who have not achieved adequate pain control at the lower dose. Maximum recommended dose for most conditions is 600mg/day. Your doctor will titrate the dose based on your response and tolerability.

Q5: Should Nervigesic 150 be taken with food?

Nervigesic 150 can be taken with or without food. Food does not significantly affect the absorption of Pregabalin. Take it at consistent times each day (for example, morning and evening) to maintain steady blood levels. Swallow the capsule whole with water.

Q6: Can I stop Nervigesic 150 suddenly?

No. Stopping Pregabalin abruptly can cause withdrawal symptoms including insomnia, nausea, headache, diarrhoea, anxiety, excessive sweating, and in some cases seizures — even in patients who were not taking it for epilepsy. Always taper the dose gradually under your doctor's guidance when stopping treatment.

Q7: Does Pregabalin cause weight gain?

Yes, weight gain is a recognised side effect of Pregabalin, occurring in a significant proportion of patients on long-term therapy. It is caused by a combination of increased appetite and peripheral oedema (fluid retention). Monitor your weight during treatment, particularly if you have diabetes, cardiovascular disease, or obesity. Discuss strategies with your doctor if weight gain is problematic.

Q8: Can I drive while taking Nervigesic 150?

Pregabalin commonly causes dizziness and somnolence (drowsiness), particularly in the first few weeks or after a dose increase. You should not drive or operate heavy machinery until you know how Nervigesic 150 affects your alertness and coordination. These effects are often worst at the start of treatment and when the dose is increased, and may improve as your body adjusts.

Q9: Is Nervigesic 150 habit-forming?

Pregabalin has recognised abuse potential, particularly at doses higher than prescribed. It has been designated a controlled substance in the UK (Schedule 3) and some EU countries due to reports of misuse and dependence. Physical dependence (requiring gradual dose reduction on stopping) can develop with regular use. Use exactly as prescribed and do not exceed the recommended dose.

Q10: Can Pregabalin be taken alongside painkillers?

Pregabalin can be combined with some painkillers but care is required. Combination with opioids (e.g., tramadol, morphine, Tapentadol) significantly increases CNS depression and respiratory depression risk — this combination should only be used under specialist guidance and at the lowest effective doses. Paracetamol (acetaminophen) and NSAIDs can generally be used alongside Pregabalin safely. Always inform your prescribing doctor of all medicines you are taking.

Q11: How should Nervigesic 150 Capsules be stored?

Store at room temperature between 15°C and 30°C. Protect from moisture and direct sunlight. Keep out of reach of children. Store in the original packaging. Do not use after the expiry date printed on the blister or bottle.

Q12: Do I need a prescription for Nervigesic 150 (Pregabalin)?

Yes. Pregabalin is a prescription-only medicine and a controlled substance in several countries. A healthcare provider should diagnose the underlying condition and prescribe Pregabalin after assessing your suitability. Kidney function should be evaluated before starting, as dose adjustment is required in patients with renal impairment.