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Melamet Cream 15g
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What is Melamet Cream Used For?
- Melasma and chloasma — hormonal facial pigmentation
- Post-inflammatory hyperpigmentation from acne, injury, or procedures
- Uneven skin tone and dark spot reduction
- Triple combination: Hydroquinone + Tretinoin + Mometasone Furoate (same actives as Melacare, different manufacturer)
How Does Melamet Cream Work?
- Hydroquinone: inhibits tyrosinase enzyme, blocking melanin synthesis
- Tretinoin: accelerates epidermal cell turnover, removing pigmented cells; improves penetration of other ingredients
- Mometasone Furoate (corticosteroid): suppresses irritation caused by hydroquinone and tretinoin, reducing rebound inflammation
How to Use Melamet Cream
Application: Apply thin layer to affected areas only at night on clean, dry skin
Timing: Nighttime only — avoid eye area, mouth, and mucous membranes
Precaution: Apply SPF 30+ sunscreen every morning — mandatory; course limited to 8–12 weeks maximum before dermatological review
Side Effects of Melamet Cream
Common Side Effects: Burning, stinging, dryness, redness, mild peeling at application site
Serious Side Effects (seek medical help): Skin atrophy with prolonged corticosteroid use, ochronosis with very extended hydroquinone use, perioral dermatitis
Benefits
- Triple mechanism simultaneously blocks melanin production, removes pigmented cells, and reduces treatment-related irritation
- Visible improvement in melasma typically seen within 4–8 weeks of consistent nightly application
- Well-tolerated triple combination — mometasone prevents the burning/irritation that limits standalone hydroquinone and tretinoin use
- Therapeutically equivalent to Melacare — same active ingredients; different manufacturer (UTL Healthcare)
- Compact 15g tube format — practical for targeted facial application
Warnings and Precautions
- Contraindicated in pregnancy — all three active ingredients are unsafe during pregnancy
- Maximum course 8–12 weeks — prolonged corticosteroid exposure causes skin thinning, striae, and telangiectasia
- Mandatory SPF 30+ daily sunscreen — UV triggers melanogenesis and reverses depigmentation
- Apply only to affected patches — avoid spreading to healthy skin, eye area, skin folds, and groin
- Extended hydroquinone use beyond 6 months risks ochronosis — irreversible grey-brown discolouration
- Do not apply to large body surface areas — systemic corticosteroid absorption risk
Drug Interactions
- Other topical retinoids on the same area: additive irritation
- Benzoyl peroxide, AHAs, BHAs, or concentrated vitamin C: excessive irritation when used on the same area
- Other topical steroids: do not apply concurrently on the same area
Storage Information
- Store at 15°C–25°C, away from heat and direct light
- Keep tube tightly capped after use; do not freeze
- Discard after the expiry date
Frequently Asked Questions
Q1: What is Melamet Cream used for?
Melamet Cream (Hydroquinone + Tretinoin + Mometasone) treats melasma, facial hyperpigmentation, dark spots, chloasma, and post-acne marks. It is a triple-combination depigmenting cream widely used in dermatology for pigmentation disorders.
Q2: What is the difference between Melamet and Melacare?
Both contain the same three active ingredients (hydroquinone + tretinoin + mometasone) and work by the same mechanism. They are from different manufacturers (UTL vs Ajanta) but are therapeutically equivalent.
Q3: How does Melamet's triple combination work?
Hydroquinone inhibits melanin production by blocking tyrosinase. Tretinoin increases cell turnover, removing pigmented cells and enhancing penetration of other ingredients. Mometasone reduces irritation caused by hydroquinone and tretinoin.
Q4: How should I apply Melamet Cream?
Apply a thin layer to affected areas only at night on clean, dry skin. Avoid eyes, mouth, and mucous membranes. Use only as prescribed — typically no longer than 8–12 weeks before dermatological reassessment.
Q5: When will Melamet Cream show visible results?
Lightening of dark spots typically begins in 4–8 weeks of nightly application. Full results are usually seen at 12 weeks. Strict daytime sun protection is essential to prevent UV-induced repigmentation.
Q6: What are the most common side effects?
Burning, stinging, redness, dryness, and mild peeling at the application site are common — particularly in the first 2–4 weeks. These usually diminish as skin adjusts.
Q7: Why is Melamet not safe for long-term use?
The mometasone corticosteroid in Melamet can cause skin atrophy, telangiectasia, and steroid acne with prolonged use. Hydroquinone can cause ochronosis (irreversible blue-grey skin discolouration) with very extended use.
Q8: Can Melamet Cream be used on the body?
Melamet is primarily used on facial pigmentation. Body use is possible for localised areas, but corticosteroid skin thinning risk increases with large-area application. Avoid skin folds, armpits, and groin where absorption is higher.
Q9: Can I use Melamet during pregnancy?
No. All three active ingredients are contraindicated during pregnancy. Consult your dermatologist for safe alternatives to treat pigmentation during pregnancy.
Q10: What sun protection is required with Melamet?
Apply broad-spectrum SPF 30+ sunscreen every morning. UV exposure rapidly reverses the depigmenting effect and can worsen melasma. Reapply sunscreen every 2 hours with sun exposure.
Q11: How should Melamet Cream be stored?
Store at room temperature (15°C–25°C) away from heat and direct light. Keep the tube tightly capped after each use.
Q12: Is a prescription required for Melamet Cream?
Yes. Melamet contains prescription-strength hydroquinone, tretinoin, and topical corticosteroid. Dermatologist prescribing and supervision are required.
Customer Reviews
Sophia F.
Germany · 4 months ago
“Three orders from Medionix for skincare products — all genuine, all on time. Consistent and trustworthy supplier.”
Noah B.
Canada · 1 month ago
“Received isotretinoin capsules within 11 days. Packaging intact and capsules are genuine. Happy with the purchase.”
Isabella D.
USA · 2 months ago
“Ordered Melacare cream. Arrived in the original sealed box with no sign of tampering. Results showing within 3 weeks.”
Mia H.
USA · 3 months ago
“The Botox arrived cold-packed in an insulated container. Completely intact. Exactly as expected from a trusted supplier.”
Emma W.
UK · 1 week ago
“Started isotretinoin from Medionix 6 weeks ago. Genuine capsules, sealed packaging. Skin is noticeably clearer already.”
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Disclaimer
The information provided on Medionix Pharma is intended for general informational purposes only. It should not be considered as medical advice, diagnosis, or treatment. Always consult a qualified healthcare professional before using any medication or starting any treatment.
Medionix Pharma does not encourage self-medication. Customers are responsible for ensuring that purchases comply with local laws and prescription requirements in their country. If you have any questions or concerns regarding the content on our website, please contact us at sales@medionixpharma.com.

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