Malegra FXT Plus Tablet
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What is Malegra FXT Plus Used For?
- Malegra FXT Plus is a dual-action combination tablet by Sunrise Remedies Pvt. Ltd. containing Sildenafil Citrate 100mg + Fluoxetine 60mg, prescribed for men with both:
- Erectile Dysfunction – Sildenafil 100mg provides PDE-5-mediated erection support for 4–6 hours.
- Premature Ejaculation via SSRI – Fluoxetine 60mg is an above-standard SSRI dose used to extend ejaculatory latency through sustained central serotonin reuptake inhibition.
- SSRI-Based PE Therapy at Higher Dose – Fluoxetine 60mg (above the standard antidepressant dose of 20–40mg) is used specifically for enhanced PE delay effect under physician direction.
How Does Malegra FXT Plus Work?
- Malegra FXT Plus delivers two active ingredients:
- Sildenafil 100mg inhibits PDE-5 in penile vasculature, sustaining cGMP-mediated blood flow for erection during arousal.
- Fluoxetine 60mg inhibits serotonin reuptake (SSRI) in the ejaculatory reflex pathway, increasing serotonin availability to delay ejaculation. Fluoxetine's long half-life (1–4 days, active metabolite 4–16 days) means PE benefit is established over weeks of daily use.
- Not an on-demand medication — daily dosing builds the sustained SSRI effect required for PE control.
How to Use Malegra FXT Plus
Dosage: One tablet daily as directed by physician.
Note: Fluoxetine PE benefit requires weeks of regular daily dosing to establish full effect.
Precaution: Contraindicated with MAOIs (14-day washout required). Contraindicated with nitrates.
Side Effects of Malegra FXT Plus
Common: Nausea, headache, insomnia, flushing, dry mouth, decreased libido, delayed orgasm.
Serious (seek medical help): Serotonin syndrome, severe hypotension, priapism, suicidal ideation.
Malegra Dosage Comparison Guide
| Strength | Best For | Onset | Duration | Link |
|---|---|---|---|---|
| 25 mg | Lower strength option | 30–60 min | 4–6 hrs | View → |
| 50 mg | Standard strength option | 30–60 min | 4–6 hrs | View → |
| 100 mg | Popular strength option | 30–60 min | 4–6 hrs | View → |
| 120 mg | Higher strength option | 30–60 min | 4–6 hrs | View → |
| 200 mg | Maximum strength variant | 30–60 min | 4–6 hrs | View → |
* Always consult your doctor before changing your dosage. This information is for educational reference only.
Drug Interactions — Important Information
| Drug / Substance | Interaction Type | Risk Level | Action Required |
|---|---|---|---|
| Nitrates (e.g., GTN, isosorbide) | Severe hypotension | 🔴 Absolute Contraindication | Do NOT combine — risk of fatal BP drop |
| Other PDE-5 inhibitors | Additive vasodilation | 🔴 Contraindicated | Never combine two PDE-5 inhibitors |
| Alpha-blockers (e.g., tamsulosin) | Additive hypotension | 🟠 Serious | Use only under physician supervision |
| Ritonavir / HIV protease inhibitors | CYP3A4 inhibition — raises sildenafil plasma level | 🟠 Serious | Reduce sildenafil dose; physician supervision required |
| Ketoconazole / Itraconazole | CYP3A4 inhibition | 🟡 Moderate | Avoid or reduce dose |
| Alcohol (heavy use) | Enhances vasodilation | 🟡 Moderate | Limit alcohol consumption |
| Grapefruit juice | CYP3A4 inhibition — slows sildenafil clearance | 🟡 Moderate | Avoid grapefruit while taking sildenafil |
Always inform your doctor about all medications, supplements, and recreational substances you are taking before starting this medication. This list is not exhaustive.
Frequently Asked Questions
Q1: What is Malegra FXT Plus?
Malegra FXT Plus is a combination tablet by Sunrise Remedies Pvt. Ltd. containing Sildenafil Citrate 100mg and Fluoxetine 60mg. Sildenafil treats erectile dysfunction and fluoxetine (an SSRI) at 60mg treats premature ejaculation by increasing serotonin availability in the ejaculatory reflex pathway.
Q2: Why is fluoxetine used for premature ejaculation?
SSRIs like fluoxetine have delayed ejaculation as a well-documented side effect that is therapeutically exploited for PE treatment. Fluoxetine increases serotonin in the ejaculatory reflex pathway, raising the ejaculatory threshold and extending intravaginal ejaculatory latency time (IELT).
Q3: Is 60mg a standard fluoxetine dose?
Standard antidepressant fluoxetine doses range from 20–40mg daily. Fluoxetine 60mg in Malegra FXT Plus is the higher range used specifically to maximise the ejaculatory delay effect under physician direction, above the antidepressant range.
Q4: Does Malegra FXT Plus work immediately for PE?
No. Fluoxetine's PE benefit is not immediate. The long half-life of fluoxetine (1–4 days) and its active metabolite norfluoxetine (4–16 days) means PE benefit develops over 2–4 weeks of regular daily use. This is a sustained-therapy medication, not on-demand like dapoxetine.
Q5: How quickly does the sildenafil component work?
Sildenafil 100mg provides erection onset within 30–60 minutes of each dose. The ED benefit is available from the first dose. Only the fluoxetine PE benefit requires weeks to establish through regular daily dosing.
Q6: What are the side effects of Malegra FXT Plus?
Fluoxetine contributes nausea (common at initiation), insomnia, decreased libido, anorgasmia, and dry mouth. Sildenafil contributes headache, flushing, nasal congestion, and visual changes. Fluoxetine's sexual side effects (delayed orgasm, decreased libido) may paradoxically be therapeutic for PE but unwanted in other contexts.
Q7: What is the washout period for MAOIs before taking Malegra FXT Plus?
A minimum 14-day MAOI-free interval is required before initiating fluoxetine. After stopping Malegra FXT Plus, a 5-week washout is needed before starting an MAOI — due to fluoxetine's extremely long half-life and the extended elimination of norfluoxetine.
Q8: Can Malegra FXT Plus be stopped abruptly?
Fluoxetine has a very long half-life that reduces the risk of acute discontinuation syndrome compared to shorter-half-life SSRIs. However, physician-guided dose reduction is still recommended for stopping fluoxetine 60mg, particularly after prolonged use.
Q9: Does fluoxetine interact with sildenafil metabolism?
Fluoxetine inhibits CYP2D6 and, to a lesser extent, CYP3A4 — the enzyme involved in sildenafil metabolism. This combination may modestly increase sildenafil plasma concentrations. Physician awareness of this pharmacokinetic interaction is important when prescribing.
Q10: Who should not take Malegra FXT Plus?
Men taking MAOIs, other serotonergic drugs, nitrates, or riociguat; those under 18; men with hepatic impairment, uncontrolled hypertension, or a history of mania; and men with cardiovascular disease incompatible with sexual activity must not use Malegra FXT Plus.
Q11: How does Malegra FXT Plus differ from Malegra FXT (30mg fluoxetine)?
Malegra FXT Plus uses Fluoxetine 60mg versus Malegra FXT's 30mg. The higher dose is intended for men who have not achieved adequate PE control at 30mg. The 30mg version is the starting dose; FXT Plus is the step-up for greater SSRI PE effect.
Q12: Is a prescription required for Malegra FXT Plus?
Yes. Fluoxetine is a prescription antidepressant with MAOI interaction risks, suicidal ideation monitoring requirements in younger patients, and specific discontinuation considerations. Physician supervision throughout therapy is important for the fluoxetine component.
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Customer Reviews
Marcus L.
UK · 2 weeks ago
“Reliable supplier. Tablets came in sealed blister packs with clear batch number and expiry date visible. Highly effective.”
Chris W.
USA · 6 weeks ago
“First order from Medionix — impressed. Product is authentic, packaging was sealed, delivery was faster than expected.”
Jack N.
France · 2 months ago
“Arrived safely in France in 14 days. Customs was not an issue. Product works as expected. Will order again.”
Nathan G.
Spain · 4 months ago
“Reasonable delivery to Spain — about 14 days. Product is exactly as described, tablets look and work authentic.”
Daniel F.
Australia · 3 weeks ago
“Good delivery time — 11 days to Sydney. Packaging was plain and discreet. Product quality matches the description exactly.”
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Clinical References
This product information is supported by peer-reviewed clinical evidence:
- Goldstein I, et al. (1998). Oral sildenafil in the treatment of erectile dysfunction. New England Journal of Medicine, 338(20), 1397–1404. [PubMed: 9580646]
- Burnett AL, et al. (2018). Erectile Dysfunction: AUA Guideline. Journal of Urology, 200(3), 633–641. [PubMed: 29746858]
- Hatzimouratidis K, et al. (2010). EAU Guidelines on Male Sexual Dysfunction. European Urology, 57(5), 804–814. [PubMed: 20189712]
- Lue TF. (2000). Erectile Dysfunction. New England Journal of Medicine, 342(24), 1802–1813. [PubMed: 10853004]
Disclaimer
The information provided on Medionix Pharma is intended for general informational purposes only. It should not be considered as medical advice, diagnosis, or treatment. Always consult a qualified healthcare professional before using any medication or starting any treatment.
Medionix Pharma does not encourage self-medication. Customers are responsible for ensuring that purchases comply with local laws and prescription requirements in their country. If you have any questions or concerns regarding the content on our website, please contact us at sales@medionixpharma.com.