Lenalid 25 mg Capsule

Q1: What is Lenalid 25mg (Lenalidomide) used for?

Lenalid 25mg is used to treat newly diagnosed and relapsed/refractory multiple myeloma (with dexamethasone), transfusion-dependent anemia in MDS with 5q deletion, and relapsed/refractory mantle cell and follicular lymphoma.

Q2: How does Lenalidomide work against myeloma?

Lenalidomide is an immunomodulatory drug (IMiD) that binds to cereblon, causing degradation of IKZF1 and IKZF3 transcription factors critical for myeloma cell survival. It also activates T-cells and NK cells against tumor cells and inhibits tumor angiogenesis.

Q3: What is the dosing cycle for Lenalid 25mg?

The standard dose is 25mg once daily on Days 1–21 of a 28-day cycle, always combined with dexamethasone. Cycles are repeated until progression or unacceptable toxicity. Dose reductions are made for adverse effects.

Q4: Why is Lenalidomide subject to a REMS program?

Lenalidomide is highly teratogenic — it causes life-threatening birth defects. The REMS (Risk Evaluation and Mitigation Strategy) program mandates two forms of contraception, monthly pregnancy testing for women, and prescription controls to prevent fetal exposure.

Q5: What are the most common side effects?

Common side effects include neutropenia (low white cells), thrombocytopenia (low platelets), anemia, diarrhea, constipation, fatigue, and muscle cramps. Blood count monitoring is mandatory.

Q6: What serious side effects require emergency care?

Seek immediate care for: DVT/pulmonary embolism (leg swelling, chest pain, shortness of breath), severe infections with fever, tumor lysis syndrome (sudden muscle pain, confusion, irregular heartbeat), or severe skin reactions.

Q7: What blood clot prevention is needed with Lenalidomide?

All patients require thromboprophylaxis — typically low-dose aspirin for standard-risk patients, and low molecular weight heparin or warfarin for high-risk patients. Risk factors include prior clots, immobility, and combination with dexamethasone.

Q8: Should Lenalid 25mg be taken with food?

It can be taken with or without food. Take at the same time each day. Swallow capsules whole — do not open, crush, or break them. If a capsule is opened, avoid skin or mucous membrane contact.

Q9: What blood tests are required during treatment?

Complete blood count (CBC) must be checked weekly for the first 8 weeks, then monthly. Kidney function and liver function tests are also monitored periodically throughout treatment.

Q10: Is Lenalidomide safe during pregnancy?

No. Lenalidomide is absolutely contraindicated in pregnancy. It is a potent teratogen that causes severe limb and other birth defects. Mandatory pregnancy prevention measures apply to all patients capable of pregnancy.

Q11: How should Lenalid capsules be stored?

Store at room temperature below 25°C, protected from moisture. Keep in the original child-resistant packaging. Dispose of unused capsules safely — they must not be discarded in household waste.

Q12: Is Lenalid available without a prescription?

No. Lenalidomide is only dispensed through authorized pharmacies under strict REMS controls. A valid prescription from an oncologist and REMS program enrollment are required.