Bevacizumab Cizumab 100mg/4ml Injection

Q1: What is Bevacizumab Cizumab used for?

Cizumab is a bevacizumab biosimilar used to treat metastatic colorectal cancer, non-small cell lung cancer, ovarian cancer, cervical cancer, and hepatocellular carcinoma — always combined with chemotherapy.

Q2: How does Cizumab work against cancer?

Cizumab binds to VEGF-A (vascular endothelial growth factor A), preventing it from activating VEGFR2 on blood vessel cells. This inhibits angiogenesis — the formation of new tumor blood vessels — starving cancer cells of oxygen and nutrients.

Q3: Is Cizumab biosimilar the same as original Avastin?

Cizumab is a biosimilar to the original bevacizumab (Avastin). It has been approved based on extensive comparability studies demonstrating equivalent efficacy, safety, and quality to the reference product at a more accessible price.

Q4: How is Cizumab administered?

It is given as an intravenous infusion — first dose over 90 minutes. If the first infusion is well tolerated, subsequent infusions may be given over 60 minutes, then 30 minutes. Treatment is typically every 2–3 weeks with chemotherapy.

Q5: What is the dose of Cizumab?

Dosing is 5–15 mg/kg every 2–3 weeks depending on the cancer type and treatment protocol. Your oncologist will determine the exact dose based on your body weight and regimen.

Q6: What are the most common side effects?

Common side effects include nosebleeds (epistaxis), high blood pressure, headache, altered taste, dry skin, and fatigue. These are generally manageable with supportive care.

Q7: What serious side effects require emergency care?

Seek immediate care for: sudden severe abdominal pain (possible GI perforation), stroke or heart attack symptoms, severe uncontrolled bleeding, wound breakdown, or severe shortness of breath.

Q8: Why must surgery be delayed around Cizumab treatment?

Bevacizumab impairs wound healing by inhibiting blood vessel formation. Treatment must be held for at least 28 days before elective surgery and should not be restarted until surgical wounds are fully healed.

Q9: Is Cizumab safe during pregnancy?

No. Bevacizumab is contraindicated in pregnancy as it causes fetal harm including malformations. Effective contraception is mandatory during treatment and for at least 6 months after the final dose.

Q10: What monitoring is required during Cizumab treatment?

Regular blood pressure monitoring, urinalysis for proteinuria, wound assessment, complete blood count, and liver function tests are required. Any surgery or invasive procedures must be coordinated with your oncologist.

Q11: How should Cizumab be stored?

Store at 2°C–8°C in the refrigerator. Do not freeze or shake. Protect from light. Keep in the original carton. Once diluted for infusion, use within 8 hours if kept at 2°C–8°C.

Q12: Is Cizumab available without a prescription?

No. Cizumab is a prescription-only biological cancer therapy administered exclusively in hospital settings under oncologist supervision.